Neurophotonic tools for microscopic measurements and manipulation: status report
Publication information:
Ahmed Abdelfattah, Sapna Ahuja, Taner Akkin, Srinivasa Rao Allu, Joshua Brake, David Boas, Erin Buckley, Robert Campbell, Anderson Chen, Xiaojun Cheng, Tomáš Čižmár, Irene Costantini, Massimo De Vittorio, Anna Devor, Patrick Doran, Mirna El Khatib, Valentina Emiliani, Natalie Fomin-Thunemann, Yeshaiahu Fainman, Tomas Fernandez-Alfonso, Christopher Ferri, Ariel Gilad, Xue Han, Andrew Harris, Elizabeth Hillman, Ute Hochgeschwender, Matthew Holt, Na Ji, Kıvılcım Kılıç, Evelyn Lake, Lei Li, Tianqi Li, Philipp Mächler, Evan Miller, Rickson Mesquita, Naga Srinivas Nadella, Valentin Nägerl, Yusuke Nasu, Axel Nimmerjahn, Petra Ondráčková, Francesco Pavone, Citlali Perez Campos, Darcy Peterka, Filippo Pisano, Ferruccio Pisanello, Francesca Puppo, Bernardo Sabatini, Sanaz Sadegh, Sava Sakadzic, Shy Shoham, Sanaya Shroff, Angus Silver, Ruth Sims, Spencer Smith, Vivek Srinivasan, Martin Thunemann, Lei Tian, Lin Tian, Thomas Troxler, Antoine Valera, Alipasha Vaziri, Sergei Vinogradov, Flavia Vitale, Lihong Wang, Hana Uhlířová, Chris Xu, Changhuei Yang, Mu-Han Yang, Gary Yellen, Ofer Yizhar, and Yongxin Zhao. 2022. “Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report”. Neurophotonics, 9, Suppl 1, Pp. 013001. doi:10.1117/1.NPh.9.S1.013001
Abstract
Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, Neurophotonics' agenda has been well aligned with this focus on neurotechnologies featuring new optical methods and tools applicable to brain studies. While the BRAIN Initiative 2.0 is pivoting towards applications of these novel tools in the quest to understand the brain, this status report reviews an extensive and diverse toolkit of novel methods to explore brain function that have emerged from the BRAIN Initiative and related large-scale efforts for measurement and manipulation of brain structure and function. Here, we focus on neurophotonic tools mostly applicable to animal studies. A companion report, scheduled to appear later this year, will cover diffuse optical imaging methods applicable to noninvasive human studies. For each domain, we outline the current state-of-the-art of the respective technologies, identify the areas where innovation is needed, and provide an outlook for the future directions.