Yellen Lab Publications

Publication Date
2010 -

Goodman RP, Markhard AL, Shah H, Sharma R, Skinner OS, Clish CB, Deik A, Patgiri A, Hsu YH, Masia R, Noh HL, Suk S, Goldberger O, Hirschhorn JN, Yellen G, Kim JK, Mootha VK. Hepatic NADH reductive stress underlies common variation in metabolic traits. Nature. 2020 Jul;583(7814):122-126. doi: 10.1038/s41586-020-2337-2. Epub 2020 May 27. PMID: 32461692

Koveal D, Díaz-García CM, Yellen G. Fluorescent Biosensors for Neuronal Metabolism and the Challenges of Quantitation. Curr Opin Neurobiol. 2020 Aug;63:111-121. doi: 10.1016/j.conb.2020.02.011. Epub 2020 Jun 16. PubMed PMID: 32559637

Díaz-García CM, Lahmann C, Martínez-François JR, Li B, Koveal D, Nathwani N, Rahman M, Keller JP, Marvin JS, Looger LL, Yellen G. Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor. J Neurosci Res. 2019 Aug;97(8):946-960. doi: 10.1002/jnr.24433. Epub 2019 May 20. PubMed PMID: 31106909; PubMed Central PMCID: PMC6565483.

Díaz-García CM, Yellen G. Neurons rely on glucose rather than astrocytic lactate during stimulation. J Neurosci Res. 2019 Aug;97(8):883-889. doi: 10.1002/jnr.24374. Epub 2018 Dec 21. Review. PubMed PMID: 30575090; PubMed Central PMCID: PMC6565458.

Yellen G. Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism. J Cell Biol. 2018 Jul 2;217(7):2235-2246. doi: 10.1083/jcb.201803152. Epub 2018 May 11. Review. PubMed PMID: 29752396; PubMed Central PMCID: PMC6028533.

Martínez-François JR, Fernández-Agüera MC, Nathwani N, Lahmann C, Burnham VL, Danial NN, Yellen G. BAD and KATP channels regulate neuron excitability and epileptiform activity. Elife. 2018 Jan 25;7. pii: e32721. doi: 10.7554/eLife.32721. PubMed PMID: 29368690; PubMed Central PMCID: PMC5785210.

Foley J, Burnham V, Tedoldi M, Danial NN, Yellen G. BAD knockout provides metabolic seizure resistance in a genetic model of epilepsy with sudden unexplained death in epilepsy. Epilepsia. 2018 Jan;59(1):e1-e4. doi: 10.1111/epi.13960. Epub 2017 Nov 23. PubMed PMID: 29171006; PubMed Central PMCID: PMC5760331.

Masia R, McCarty WJ, Lahmann C, Luther J, Chung RT, Yarmush ML, Yellen G. Live cell imaging of cytosolic NADH/NAD+ ratio in hepatocytes and liver slices. Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G97-G108. doi: 10.1152/ajpgi.00093.2017. Epub 2017 Oct 12. PubMed PMID: 29025729.

Díaz-García CM, Mongeon R, Lahmann C, Koveal D, Zucker H, Yellen G. Neuronal stimulation triggers neuronal glycolysis and not lactate uptake. Cell Metab. 2017 Aug 1;26(2):361-374.e4. doi: 10.1016/j.cmet.2017.06.021. PubMed PMID: 28768175; PubMed Central PMCID: PMC5559896.

Hung YP, Teragawa C, Kosaisawe N, Gillies TE, Pargett M, Minguet M, Distor K, Rocha-Gregg BL, Coloff JL, Keibler MA, Stephanopoulos G, Yellen G, Brugge JS, Albeck JG. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife. 2017 Dec 14;6. pii: e27293. doi: 10.7554/eLife.27293. PubMed PMID: 29239720; PubMed Central PMCID: PMC5730373.

Lutas A, Lahmann C, Soumillon M, Yellen G. The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons. Elife. 2016 May 13;5. pii: e15271. doi: 10.7554/eLife.15271.

Mongeon R, Venkatachalam V, Yellen G. Cytosolic NADH-NAD+ redox visualized in brain slices by two-photon fluorescence lifetime biosensor imaging. Antioxid Redox Signal. 2016 Mar 18. [Epub ahead of print].

Yellen G, Mongeon R. Quantitative two-photon imaging of fluorescent biosensors. Curr Opin Chem Biol. 2015 Jun 12;27:24-30.

Masia R, Krause DS, Yellen G. The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver. Am J Physiol Cell Physiol. 2015 Feb 1;308(3):C264-76.

Lutas A, Birnbaumer L, Yellen G. Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J Neurosci. 2014 Dec 3;34(49):16336-47. Free via Pubmed.

Tantama M, Yellen G. Imaging changes in the cytosolic ATP-to-ADP ratio. Methods Enzymol. 2014;547:355-71. Free via Pubmed.

Chen Y, Saulnier JL, Yellen G, Sabatini BL. A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging. Front Pharmacol. 2014 Apr 2;5:56. Journal Link (Open Access)

Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, Kim D, Le A, Yellen G, Albeck JG, Locasale JW. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife (Cambridge). 2014 Jul 9:e03342. Journal Link (Open Access)

Tantama M, Martínez-François JR, Mongeon R, Yellen G. Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio. Nat Commun. 2013;4:2550. Journal Link Free PMC full-text

Hung YP, Yellen G. Live-cell imaging of cytosolic NADH-NAD+ redox state using a genetically encoded fluorescent biosensor. Methods Mol Biol. 2014;1071:83-95. Journal Link

Lutas A, Yellen G. The ketogenic diet: metabolic influences on brain excitability and epilepsy. Trends Neurosci. 2013 Jan;36(1):32-40. Journal Link Free PMC full-text

Tantama M, Hung YP, Yellen G. Optogenetic reporters: Fluorescent protein-based genetically encoded indicators of signaling and metabolism in the brain. Prog Brain Res. 2012;196:235-63. Free PMC full-text

Giménez-Cassina A, Martínez-François JR, Fisher JK, Szlyk B, Polak K, Wiwczar J, Tanner GR, Lutas A, Yellen G*, Danial NN*.   BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures.  Neuron 2012 May 24;74(4):719-730. Journal link  *co-corresponding authors  Preview by Ziviani and Scorrano

Kwan DC, Prole DL, Yellen G.  Structural changes during HCN channel gating defined by high affinity metal bridges.  J Gen Physiol 2012;140(3):279-291. pdf; Commentary by Trudeau

Ryu S, Yellen G.  Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.  J Gen Physiol 2012;140(5):469-479. pdf; Commentary by Trudeau

Hung YP, Albeck JG, Tantama M, Yellen G.  Imaging Cytosolic NADH-NAD+ Redox State with a Genetically Encoded Fluorescent Biosensor.  Cell Metab. 2011 Oct 5;14(4):545-54. Journal Link (Featured Article) pdf, Supplement pdf

Tanner GR, Lutas A, Martínez-François JR, Yellen G.  Single KATP channel opening in response to action potential firing in mouse dentate granule neurons.  J Neurosci. 2011 Jun 8;31(23):8689-96. Free from the journal

Tantama M, Hung YP, Yellen G.  Imaging intracellular pH in live cells with a genetically encoded red fluorescent protein sensor.  J Am Chem Soc. 2011 Jul 6;133(26):10034-7. Epub 2011 Jun 9. Free from Pubmed Central

2000 - 2009

Berg J, Hung YP, Yellen G.  A genetically encoded fluorescent reporter of ATP:ADP ratio.  Nat Methods. 2009 Feb;6(2):161-6. Epub 2009 Jan 4. pdf, Supplement pdf

Yellen G.  Ketone bodies, glycolysis, and KATP channels in the mechanism of the ketogenic diet.  Epilepsia. 2008 Nov;49 Suppl 8:80-2. pdf

Ma W, Berg J, Yellen G.  Ketogenic diet metabolites reduce firing in central neurons by opening KATP channels.  J Neurosci. 2007 Apr 4;27(14):3618-25. free via Pubmed

Dekker JP, Yellen G.  Cooperative gating between single HCN pacemaker channels.  J Gen Physiol. 2006 Nov;128(5):561-7. Epub 2006 Oct 16. free via Pubmed

Prole DL, Yellen G.  Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.  J Gen Physiol. 2006 Sep;128(3):273-82. Epub 2006 Aug 14. free via Pubmed

Proenza C, Yellen G.  Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents.  J Gen Physiol. 2006 Feb;127(2):183-90. free via Pubmed

del Camino D, Kanevsky M, Yellen G.  Status of the intracellular gate in the activated-not-open state of Shaker K+ channels.  J Gen Physiol. 2005 Nov;126(5):419-28. free via Pubmed

Webster SM, Del Camino D, Dekker JP, Yellen G.  Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.  Nature. 2004 Apr 22;428(6985):864-8. pdf

Shin KS, Maertens C, Proenza C, Rothberg BS, Yellen G.  Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage.  Neuron. 2004 Mar 4;41(5):737-44. pdf

Dekker JP, Fodor A, Aldrich RW, Yellen G.  A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments.  Bioinformatics. 2004 Jul 10;20(10):1565-72. Epub 2004 Feb 12. free via Pubmed

Rothberg BS, Shin KS, Yellen G.  Movements near the gate of a hyperpolarization-activated cation channel.  J Gen Physiol. 2003 Nov;122(5):501-10. Epub 2003 Oct 13. free via Pubmed

Yellen G.  The voltage-gated potassium channels and their relatives.  Nature. 2002 Sep 5;419(6902):35-42. pdf

Smith PL, Yellen G.  Fast and slow voltage sensor movements in HERG potassium channels.  J Gen Physiol. 2002 Mar;119(3):275-93. free via Pubmed

Rothberg BS, Shin KS, Phale PS, Yellen G.  Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel.  J Gen Physiol. 2002 Jan;119(1):83-91. free via Pubmed

Yellen G.  Keeping K+ completely comfortable.  Nat Struct Biol. 2001 Dec;8(12):1011-3.

del Camino D, Yellen G.  Tight steric closure at the intracellular activation gate of a voltage-gated K+ channel.  Neuron. 2001 Nov 20;32(4):649-56. pdf

Yellen G.  Dimers among friends: ion channel regulation by dimerization of tail domains.  Trends Pharmacol Sci. 2001 Sep;22(9):439-41.

Shin KS, Rothberg BS, Yellen G.  Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate.  J Gen Physiol. 2001 Feb;117(2):91-101. free via Pubmed

del Camino D, Holmgren M, Liu Y, Yellen G.  Blocker protection in the pore of a voltage-gated K+ channel and its structural implications.  Nature. 2000 Jan 20;403(6767):321-5. pdf

1990 - 1999

Yellen G.  The bacterial K+ channel structure and its implications for neuronal channels.  Curr Opin Neurobiol. 1999 Jun;9(3):267-73.

Yellen G.  The moving parts of voltage-gated ion channels.  Q Rev Biophys. 1998 Aug;31(3):239-95. pdf

Holmgren M, Shin KS, Yellen G.  The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge.  Neuron. 1998 Sep;21(3):617-21. pdf

Yellen G.  Premonitions of ion channel gating.  Nat Struct Biol. 1998 Jun;5(6):421.

Yellen G.  Single channel seeks permeant ion for brief but intimate relationship.  J Gen Physiol. 1997 Aug;110(2):83-5. free via Pubmed

Liu Y, Holmgren M, Jurman ME, Yellen G.  Gated access to the pore of a voltage-dependent K+ channel.  Neuron. 1997 Jul;19(1):175-84. pdf

Holmgren M, Smith PL, Yellen G.  Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating.  J Gen Physiol. 1997 May;109(5):527-35. free via Pubmed

Baker K, Warren KS, Yellen G, Fishman MC.  Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate.  Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4554-9. free via Pubmed

Baukrowitz T, Yellen G.  Two functionally distinct subsites for the binding of internal blockers to the pore of voltage-activated K+ channels.  Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13357-61. free via Pubmed

Holmgren M, Jurman ME, Yellen G.  N-type inactivation and the S4-S5 region of the Shaker K+ channel.  J Gen Physiol. 1996 Sep;108(3):195-206. free via Pubmed

Forman SA, Yellen G, Thiele EA.  Alternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation.  Nat Genet. 1996 Aug;13(4):396-7. pdf

Liu Y, Jurman ME, Yellen G.  Dynamic rearrangement of the outer mouth of a K+ channel during gating.  Neuron. 1996 Apr;16(4):859-67. pdf

Smith PL, Baukrowitz T, Yellen G.  The inward rectification mechanism of the HERG cardiac potassium channel.  Nature. 1996 Feb 29;379(6568):833-6. pdf

Baukrowitz T, Yellen G.  Use-dependent blockers and exit rate of the last ion from the multi-ion pore of a K+ channel.  Science. 1996 Feb 2;271(5249):653-6. pdf

Holmgren M, Liu Y, Xu Y, Yellen G.  On the use of thiol-modifying agents to determine channel topology.  Neuropharmacology. 1996;35(7):797-804. pdf

Baukrowitz T, Yellen G. Modulation of K+ current by frequency and external K+: a tale of two inactivation mechanisms. Neuron. 1995 Oct;15(4):951-60. pdf

Forman SA, Miller KW, Yellen G.  A discrete site for general anesthetics on a postsynaptic receptor.  Mol Pharmacol. 1995 Oct;48(4):574-81.

McLaughlin JT, Hawrot E, Yellen G.  Covalent modification of engineered cysteines in the nicotinic acetylcholine receptor agonist-binding domain inhibits receptor activation.  Biochem J. 1995 Sep 15;310 ( Pt 3):765-9. free via Pubmed

Jurman ME, Boland LM, Liu Y, Yellen G.  Visual identification of individual transfected cells for electrophysiology using antibody-coated beads.  Biotechniques. 1994 Nov;17(5):876-81.

Yellen G, Sodickson D, Chen TY, Jurman ME.  An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding.  Biophys J. 1994 Apr;66(4):1068-75. free via Pubmed

Boland LM, Jurman ME, Yellen G.  Cysteines in the Shaker K+ channel are not essential for channel activity or zinc modulation.  Biophys J. 1994 Mar;66(3 Pt 1):694-9. free via Pubmed

Kienker P, Tomaselli G, Jurman M, Yellen G.  Conductance mutations of the nicotinic acetylcholine receptor do not act by a simple electrostatic mechanism.  Biophys J. 1994 Feb;66(2 Pt 1):325-34. free via Pubmed

Yellen G.  Calcium channels. Structure and selectivity.  Nature. 1993 Nov 11;366(6451):109-10.

Choi KL, Mossman C, Aube J, Yellen G.  The internal quaternary ammonium receptor site of Shaker potassium channels.  Neuron. 1993 Mar;10(3):533-41. pdf

Hwang PM, Glatt CE, Bredt DS, Yellen G, Snyder SH.  A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization.  Neuron. 1992 Mar;8(3):473-81.

Demo SD, Yellen G.  Ion effects on gating of the Ca2+-activated K+ channel correlate with occupancy of the pore.  Biophys J. 1992 Mar;61(3):639-48. free via Pubmed

Demo SD, Yellen G.  The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker.  Neuron. 1991 Nov;7(5):743-53. pdf

Tomaselli GF, McLaughlin JT, Jurman ME, Hawrot E, Yellen G.  Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor.  Biophys J. 1991 Sep;60(3):721-7. free via Pubmed

Choi KL, Aldrich RW, Yellen G.  Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels.  Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5092-5. free via Pubmed

Yellen G, Jurman ME, Abramson T, MacKinnon R.  Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel.  Science. 1991 Feb 22;251(4996):939-42. pdf

MacKinnon R, Yellen G.  Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels.  Science. 1990 Oct 12;250(4978):276-9. pdf

Tomaselli GF, Feldman AM, Yellen G, Marban E.  Human cardiac sodium channels expressed in Xenopus oocytes.  Am J Physiol. 1990 Mar;258(3 Pt 2):H903-6.

Yellen G, Migeon JC.  Expression of Torpedo nicotinic acetylcholine receptor subunits in yeast is enhanced by use of yeast signal sequences.  Gene. 1990 Feb 14;86(2):145-52.

1982 - 1989

Tomaselli GF, Marban E, Yellen G.  Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin.  J Clin Invest. 1989 May;83(5):1724-32.

Yellen G.  Permeation in potassium channels: implications for channel structure.  Annu Rev Biophys Biophys Chem. 1987;16:227-46.

Cukierman S, Yellen G, Miller C.  The K+ channel of sarcoplasmic reticulum. A new look at Cs+ block.  Biophys J. 1985 Sep;48(3):477-84. free via Pubmed

Yellen G.  Relief of Na+ block of Ca2+-activated K+ channels by external cations.  J Gen Physiol. 1984 Aug;84(2):187-99. free via Pubmed

Yellen G.  Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cells.  J Gen Physiol. 1984 Aug;84(2):157-86. free via Pubmed

Reuter H, Stevens CF, Tsien RW, Yellen G.  Properties of single calcium channels in cardiac cell culture.  Nature. 1982 Jun 10;297(5866):501-4.

Yellen G.  Single Ca2+-activated nonselective cation channels in neuroblastoma.  Nature. 1982 Mar 25;296(5855):357-9.

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