# Publications Download 20 citations download- [BibTeX](/bibcite/export?pager_style=no_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=no_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=no_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=no_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=tagged) - [Marc](/bibcite/export?pager_style=no_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=marc) - [PubMedId](/bibcite/export?pager_style=no_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=no_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=ris) ### 2025 Paul C. Rosen, Andrew Glaser, Juan R. Martínez-François, Daniel C. Lim, Daniel J. Brooks, Panhui Fu, Erica Kim, Dorothee Kern, and Gary Yellen. 2025. “[Mechanism and Application of Thiol–disulfide Redox Biosensors With a Fluorescence-Lifetime Readout](https://www.pnas.org/doi/10.1073/pnas.2503978122)”. PNAS, 122, 19. doi:10.1073/pnas.2503978122 Paul C. Rosen, Andrew Glaser, Juan R. Martínez-François, Daniel C. Lim, Daniel J. Brooks, Panhui Fu, Erica Kim, Dorothee Kern, and Gary Yellen. 2025. “[Mechanism and Application of Thiol–disulfide Redox Biosensors With a Fluorescence-Lifetime Readout](https://www.pnas.org/doi/10.1073/pnas.2503978122)”. PNAS, 122, 19. doi:10.1073/pnas.2503978122 - add\_circle do\_not\_disturb\_on Abstract Genetically encoded biosensors with changes in fluorescence lifetime (as opposed to fluorescence intensity) can quantify small molecules in complex contexts, even in vivo. However, lifetime-readout sensors are poorly understood at a molecular level... Paul C. Rosen, Samantha M. Horwitz, Daniel J. Brooks, Erica Kim, Joseph A. Ambari, Lidia Waidmann, Katherine M. Davis, and Gary Yellen. 2025. “[State-Dependent Motion of a Genetically Encoded Fluorescent Biosensor](https://www.pnas.org/doi/10.1073/pnas.2426324122)”. PNAS, 122, 10. doi:10.1073/pnas.2426324122 Paul C. Rosen, Samantha M. Horwitz, Daniel J. Brooks, Erica Kim, Joseph A. Ambari, Lidia Waidmann, Katherine M. Davis, and Gary Yellen. 2025. “[State-Dependent Motion of a Genetically Encoded Fluorescent Biosensor](https://www.pnas.org/doi/10.1073/pnas.2426324122)”. PNAS, 122, 10. doi:10.1073/pnas.2426324122 - add\_circle do\_not\_disturb\_on Abstract Genetically encoded biosensors can measure biochemical properties such as small-molecule concentrations with single-cell resolution, even in vivo. Despite their utility, these sensors are “black boxes”: Very little is known about the structures of their... Paul Rosen, Panhui Fu, Beatriz Ferrán, Erica Kim, Daniel J. Brooks, Daniel C. Lim, Carlos Manlio Díaz-García, and Gary Yellen. 2025. “[Activity-Dependent Citrate Dynamics in Neurons](/publication/activity-dependent-citrate-dynamics-neurons)”. doi:10.1073/pnas.2519902122 Paul Rosen, Panhui Fu, Beatriz Ferrán, Erica Kim, Daniel J. Brooks, Daniel C. Lim, Carlos Manlio Díaz-García, and Gary Yellen. 2025. “[Activity-Dependent Citrate Dynamics in Neurons](/publication/activity-dependent-citrate-dynamics-neurons)”. doi:10.1073/pnas.2519902122 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.pnas.org/doi/10.1073/pnas.2519902122) Glycolytic enzymes sense metabolite levels to adapt rapidly to changing energy demands, but measuring the levels of these effectors with spatiotemporal precision in live cells has been challenging. We addressed this question in the context of neuronal... - [ descriptionPublisher's Version](https://www.pnas.org/doi/10.1073/pnas.2519902122) ### 2024 Elisa York, Anne Miller, Sylwia Stopka, Juan Ramón Martínez-François, Md Amin Hossain, Gerard Baquer, Michael Regan, Nathalie Agar, and Gary Yellen. 2024. “[The Dentate Gyrus Differentially Metabolizes Glucose and Alternative Fuels During Rest and Stimulation](/publications/dentate-gyrus-differentially-metabolizes-glucose-and-alternative-fuels-during)”. J Neurochem. doi:10.1111/jnc.16004 Elisa York, Anne Miller, Sylwia Stopka, Juan Ramón Martínez-François, Md Amin Hossain, Gerard Baquer, Michael Regan, Nathalie Agar, and Gary Yellen. 2024. “[The Dentate Gyrus Differentially Metabolizes Glucose and Alternative Fuels During Rest and Stimulation](/publications/dentate-gyrus-differentially-metabolizes-glucose-and-alternative-fuels-during)”. J Neurochem. doi:10.1111/jnc.16004 - add\_circle do\_not\_disturb\_on Abstract The metabolic demands of neuronal activity are both temporally and spatially dynamic, and neurons are particularly sensitive to disruptions in fuel and oxygen supply. Glucose is considered an obligate fuel for supporting brain metabolism. Although... ### 2023 Anne Miller, Elisa York, Sylwia Stopka, Juan Ramón Martínez-François, Md Amin Hossain, Gerard Baquer, Michael Regan, Nathalie Agar, and Gary Yellen. 2023. “[Spatially Resolved Metabolomics and Isotope Tracing Reveal Dynamic Metabolic Responses of Dentate Granule Neurons With Acute Stimulation](/publications/spatially-resolved-metabolomics-and-isotope-tracing-reveal-dynamic-metabolic)”. Nat Metab, 5, 10, Pp. 1820-35. doi:10.1038/s42255-023-00890-z Anne Miller, Elisa York, Sylwia Stopka, Juan Ramón Martínez-François, Md Amin Hossain, Gerard Baquer, Michael Regan, Nathalie Agar, and Gary Yellen. 2023. “[Spatially Resolved Metabolomics and Isotope Tracing Reveal Dynamic Metabolic Responses of Dentate Granule Neurons With Acute Stimulation](/publications/spatially-resolved-metabolomics-and-isotope-tracing-reveal-dynamic-metabolic)”. Nat Metab, 5, 10, Pp. 1820-35. doi:10.1038/s42255-023-00890-z - add\_circle do\_not\_disturb\_on Abstract Neuronal activity creates an intense energy demand that must be met by rapid metabolic responses. To investigate metabolic adaptations in the neuron-enriched dentate granule cell (DGC) layer within its native tissue environment, we employed murine acute... Margarete Diaz-Cuadros, Teemu Miettinen, Owen Skinner, Dylan Sheedy, Carlos Manlio Díaz-García, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott Manalis, William Oldham, and Olivier Pourquié. 2023. “[Metabolic Regulation of Species-Specific Developmental Rates](/publications/metabolic-regulation-species-specific-developmental-rates)”. Nature, 613, 7944, Pp. 550-57. doi:10.1038/s41586-022-05574-4 Margarete Diaz-Cuadros, Teemu Miettinen, Owen Skinner, Dylan Sheedy, Carlos Manlio Díaz-García, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott Manalis, William Oldham, and Olivier Pourquié. 2023. “[Metabolic Regulation of Species-Specific Developmental Rates](/publications/metabolic-regulation-species-specific-developmental-rates)”. Nature, 613, 7944, Pp. 550-57. doi:10.1038/s41586-022-05574-4 - add\_circle do\_not\_disturb\_on Abstract Animals display substantial inter-species variation in the rate of embryonic development despite a broad conservation of the overall sequence of developmental events. Differences in biochemical reaction rates, including the rates of protein production and... ### 2022 Dylan Meyer, Carlos Manlio Díaz-García, Nidhi Nathwani, Mahia Rahman, and Gary Yellen. 2022. “[The Na K Pump Dominates Control of Glycolysis in Hippocampal Dentate Granule Cells](/publications/nak-pump-dominates-control-glycolysis-hippocampal-dentate-granule-cells)”. Elife, 11. doi:10.7554/eLife.81645 Dylan Meyer, Carlos Manlio Díaz-García, Nidhi Nathwani, Mahia Rahman, and Gary Yellen. 2022. “[The Na K Pump Dominates Control of Glycolysis in Hippocampal Dentate Granule Cells](/publications/nak-pump-dominates-control-glycolysis-hippocampal-dentate-granule-cells)”. Elife, 11. doi:10.7554/eLife.81645 - add\_circle do\_not\_disturb\_on Abstract Cellular ATP that is consumed to perform energetically expensive tasks must be replenished by new ATP through the activation of metabolism. Neuronal stimulation, an energetically demanding process, transiently activates aerobic glycolysis, but the precise... Dorothy Koveal, Paul Rosen, Dylan Meyer, Carlos Manlio Díaz-García, Yongcheng Wang, Li-Heng Cai, Peter Chou, David Weitz, and Gary Yellen. 2022. “[A High-Throughput Multiparameter Screen for Accelerated Development and Optimization of Soluble Genetically Encoded Fluorescent Biosensors](/publications/high-throughput-multiparameter-screen-accelerated-development-and-optimization)”. Nat Commun, 13, 1, Pp. 2919. doi:10.1038/s41467-022-30685-x Dorothy Koveal, Paul Rosen, Dylan Meyer, Carlos Manlio Díaz-García, Yongcheng Wang, Li-Heng Cai, Peter Chou, David Weitz, and Gary Yellen. 2022. “[A High-Throughput Multiparameter Screen for Accelerated Development and Optimization of Soluble Genetically Encoded Fluorescent Biosensors](/publications/high-throughput-multiparameter-screen-accelerated-development-and-optimization)”. Nat Commun, 13, 1, Pp. 2919. doi:10.1038/s41467-022-30685-x - add\_circle do\_not\_disturb\_on Abstract Genetically encoded fluorescent biosensors are powerful tools used to track chemical processes in intact biological systems. However, the development and optimization of biosensors remains a challenging and labor-intensive process, primarily due to... Ahmed Abdelfattah, Sapna Ahuja, Taner Akkin, Srinivasa Rao Allu, Joshua Brake, David Boas, Erin Buckley, Robert Campbell, Anderson Chen, Xiaojun Cheng, Tomáš Čižmár, Irene Costantini, Massimo De Vittorio, Anna Devor, Patrick Doran, Mirna El Khatib, Valentina Emiliani, Natalie Fomin-Thunemann, Yeshaiahu Fainman, Tomas Fernandez-Alfonso, Christopher Ferri, Ariel Gilad, Xue Han, Andrew Harris, Elizabeth Hillman, Ute Hochgeschwender, Matthew Holt, Na Ji, Kıvılcım Kılıç, Evelyn Lake, Lei Li, Tianqi Li, Philipp Mächler, Evan Miller, Rickson Mesquita, Naga Srinivas Nadella, Valentin Nägerl, Yusuke Nasu, Axel Nimmerjahn, Petra Ondráčková, Francesco Pavone, Citlali Perez Campos, Darcy Peterka, Filippo Pisano, Ferruccio Pisanello, Francesca Puppo, Bernardo Sabatini, Sanaz Sadegh, Sava Sakadzic, Shy Shoham, Sanaya Shroff, Angus Silver, Ruth Sims, Spencer Smith, Vivek Srinivasan, Martin Thunemann, Lei Tian, Lin Tian, Thomas Troxler, Antoine Valera, Alipasha Vaziri, Sergei Vinogradov, Flavia Vitale, Lihong Wang, Hana Uhlířová, Chris Xu, Changhuei Yang, Mu-Han Yang, Gary Yellen, Ofer Yizhar, and Yongxin Zhao. 2022. “[Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report](/publications/neurophotonic-tools-microscopic-measurements-and-manipulation-status-report)”. Neurophotonics, 9, Suppl 1, Pp. 013001. doi:10.1117/1.NPh.9.S1.013001 Ahmed Abdelfattah, Sapna Ahuja, Taner Akkin, Srinivasa Rao Allu, Joshua Brake, David Boas, Erin Buckley, Robert Campbell, Anderson Chen, Xiaojun Cheng, Tomáš Čižmár, Irene Costantini, Massimo De Vittorio, Anna Devor, Patrick Doran, Mirna El Khatib, Valentina Emiliani, Natalie Fomin-Thunemann, Yeshaiahu Fainman, Tomas Fernandez-Alfonso, Christopher Ferri, Ariel Gilad, Xue Han, Andrew Harris, Elizabeth Hillman, Ute Hochgeschwender, Matthew Holt, Na Ji, Kıvılcım Kılıç, Evelyn Lake, Lei Li, Tianqi Li, Philipp Mächler, Evan Miller, Rickson Mesquita, Naga Srinivas Nadella, Valentin Nägerl, Yusuke Nasu, Axel Nimmerjahn, Petra Ondráčková, Francesco Pavone, Citlali Perez Campos, Darcy Peterka, Filippo Pisano, Ferruccio Pisanello, Francesca Puppo, Bernardo Sabatini, Sanaz Sadegh, Sava Sakadzic, Shy Shoham, Sanaya Shroff, Angus Silver, Ruth Sims, Spencer Smith, Vivek Srinivasan, Martin Thunemann, Lei Tian, Lin Tian, Thomas Troxler, Antoine Valera, Alipasha Vaziri, Sergei Vinogradov, Flavia Vitale, Lihong Wang, Hana Uhlířová, Chris Xu, Changhuei Yang, Mu-Han Yang, Gary Yellen, Ofer Yizhar, and Yongxin Zhao. 2022. “[Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report](/publications/neurophotonic-tools-microscopic-measurements-and-manipulation-status-report)”. Neurophotonics, 9, Suppl 1, Pp. 013001. doi:10.1117/1.NPh.9.S1.013001 - add\_circle do\_not\_disturb\_on Abstract *Neurophotonics* was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, *Neurophotonics*' agenda has been well aligned with this focus on... ### 2021 Carlos Manlio Díaz-García, Nidhi Nathwani, Juan Ramón Martínez-François, and Gary Yellen. 2021. “[Delivery of AAV for Expression of Fluorescent Biosensors in Juvenile Mouse Hippocampus](/publications/delivery-aav-expression-fluorescent-biosensors-juvenile-mouse-hippocampus-0)”. Bio Protoc, 11, 24, Pp. e4259. doi:10.21769/BioProtoc.4259 Carlos Manlio Díaz-García, Nidhi Nathwani, Juan Ramón Martínez-François, and Gary Yellen. 2021. “[Delivery of AAV for Expression of Fluorescent Biosensors in Juvenile Mouse Hippocampus](/publications/delivery-aav-expression-fluorescent-biosensors-juvenile-mouse-hippocampus-0)”. Bio Protoc, 11, 24, Pp. e4259. doi:10.21769/BioProtoc.4259 - add\_circle do\_not\_disturb\_on Abstract Genetically encoded fluorescent biosensors are versatile tools for studying brain metabolism and function in live tissue. The genetic information for these biosensors can be delivered into the brain by stereotaxic injection of engineered adeno-associated... Mackenzie Cervenka, Juan Pascual, Jong Rho, Elizabeth Thiele, Gary Yellen, Vicky Whittemore, and Adam Hartman. 2021. “[Metabolism-Based Therapies for Epilepsy: New Directions for Future Cures](/publications/metabolism-based-therapies-epilepsy-new-directions-future-cures)”. Ann Clin Transl Neurol, 8, 8, Pp. 1730-37. doi:10.1002/acn3.51423 Mackenzie Cervenka, Juan Pascual, Jong Rho, Elizabeth Thiele, Gary Yellen, Vicky Whittemore, and Adam Hartman. 2021. “[Metabolism-Based Therapies for Epilepsy: New Directions for Future Cures](/publications/metabolism-based-therapies-epilepsy-new-directions-future-cures)”. Ann Clin Transl Neurol, 8, 8, Pp. 1730-37. doi:10.1002/acn3.51423 - add\_circle do\_not\_disturb\_on Abstract OBJECTIVE: Thousands of years after dietary therapy was proposed to treat seizures, how alterations in metabolism relates to epilepsy remains unclear, and metabolism-based therapies are not always effective.METHODS: We consider the state of the science in... Carlos Manlio Díaz-García, Dylan Meyer, Nidhi Nathwani, Mahia Rahman, Juan Ramón Martínez-François, and Gary Yellen. 2021. “[The Distinct Roles of Calcium in Rapid Control of Neuronal Glycolysis and the Tricarboxylic Acid Cycle](/publications/distinct-roles-calcium-rapid-control-neuronal-glycolysis-and-tricarboxylic-acid)”. Elife, 10. doi:10.7554/eLife.64821 Carlos Manlio Díaz-García, Dylan Meyer, Nidhi Nathwani, Mahia Rahman, Juan Ramón Martínez-François, and Gary Yellen. 2021. “[The Distinct Roles of Calcium in Rapid Control of Neuronal Glycolysis and the Tricarboxylic Acid Cycle](/publications/distinct-roles-calcium-rapid-control-neuronal-glycolysis-and-tricarboxylic-acid)”. Elife, 10. doi:10.7554/eLife.64821 - add\_circle do\_not\_disturb\_on Abstract When neurons engage in intense periods of activity, the consequent increase in energy demand can be met by the coordinated activation of glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation. However, the trigger for glycolytic... Carlos Manlio Díaz-García, Nidhi Nathwani, Juan Ramón Martínez-François, and Gary Yellen. 2021. “[Delivery of AAV for Expression of Fluorescent Biosensors in Juvenile Mouse Hippocampus.](/publications/delivery-aav-expression-fluorescent-biosensors-juvenile-mouse-hippocampus)”. BioProtocols, 11, 24:e4259 Carlos Manlio Díaz-García, Nidhi Nathwani, Juan Ramón Martínez-François, and Gary Yellen. 2021. “[Delivery of AAV for Expression of Fluorescent Biosensors in Juvenile Mouse Hippocampus.](/publications/delivery-aav-expression-fluorescent-biosensors-juvenile-mouse-hippocampus)”. BioProtocols, 11, 24:e4259 - add\_circle do\_not\_disturb\_on Abstract Genetically encoded fluorescent biosensors are versatile tools for studying brain metabolism and function in live tissue. The genetic information for these biosensors can be delivered into the brain by stereotaxic injection of engineered adeno-associated... ### 2020 Dorothy Koveal, Carlos Manlio Díaz-García, and Gary Yellen. 2020. “[Fluorescent Biosensors for Neuronal Metabolism and the Challenges of Quantitation](/publications/fluorescent-biosensors-neuronal-metabolism-and-challenges-quantitation)”. Curr Opin Neurobiol, 63, Pp. 111-21. doi:10.1016/j.conb.2020.02.011 Dorothy Koveal, Carlos Manlio Díaz-García, and Gary Yellen. 2020. “[Fluorescent Biosensors for Neuronal Metabolism and the Challenges of Quantitation](/publications/fluorescent-biosensors-neuronal-metabolism-and-challenges-quantitation)”. Curr Opin Neurobiol, 63, Pp. 111-21. doi:10.1016/j.conb.2020.02.011 - add\_circle do\_not\_disturb\_on Abstract Over the past decade, genetically encoded fluorescent biosensors that report metabolic changes have become valuable tools for understanding brain metabolism. These sensors have been targeted to specific brain regions and cell types in different organisms... Russell Goodman, Andrew Markhard, Hardik Shah, Rohit Sharma, Owen Skinner, Clary Clish, Amy Deik, Anupam Patgiri, Yu-Han Hsu, Ricard Masia, Hye Lim Noh, Sujin Suk, Olga Goldberger, Joel Hirschhorn, Gary Yellen, Jason Kim, and Vamsi Mootha. 2020. “[Hepatic NADH Reductive Stress Underlies Common Variation in Metabolic Traits](/publications/hepatic-nadh-reductive-stress-underlies-common-variation-metabolic-traits)”. Nature, 583, 7814, Pp. 122-26. doi:10.1038/s41586-020-2337-2 Russell Goodman, Andrew Markhard, Hardik Shah, Rohit Sharma, Owen Skinner, Clary Clish, Amy Deik, Anupam Patgiri, Yu-Han Hsu, Ricard Masia, Hye Lim Noh, Sujin Suk, Olga Goldberger, Joel Hirschhorn, Gary Yellen, Jason Kim, and Vamsi Mootha. 2020. “[Hepatic NADH Reductive Stress Underlies Common Variation in Metabolic Traits](/publications/hepatic-nadh-reductive-stress-underlies-common-variation-metabolic-traits)”. Nature, 583, 7814, Pp. 122-26. doi:10.1038/s41586-020-2337-2 - add\_circle do\_not\_disturb\_on Abstract The cellular NADH/NAD+ ratio is fundamental to biochemistry, but the extent to which it reflects versus drives metabolic physiology in vivo is poorly understood. Here we report the in vivo application of Lactobacillus brevis (Lb)NOX1, a bacterial water... ### 2019 Carlos Manlio Díaz-García, Carolina Lahmann, Juan Ramón Martínez-François, Binsen Li, Dorothy Koveal, Nidhi Nathwani, Mahia Rahman, Jacob Keller, Jonathan Marvin, Loren Looger, and Gary Yellen. 2019. “[Quantitative in Vivo Imaging of Neuronal Glucose Concentrations With a Genetically Encoded Fluorescence Lifetime Sensor](/publications/quantitative-vivo-imaging-neuronal-glucose-concentrations-genetically-encoded)”. J Neurosci Res, 97, 8, Pp. 946-60. doi:10.1002/jnr.24433 Carlos Manlio Díaz-García, Carolina Lahmann, Juan Ramón Martínez-François, Binsen Li, Dorothy Koveal, Nidhi Nathwani, Mahia Rahman, Jacob Keller, Jonathan Marvin, Loren Looger, and Gary Yellen. 2019. “[Quantitative in Vivo Imaging of Neuronal Glucose Concentrations With a Genetically Encoded Fluorescence Lifetime Sensor](/publications/quantitative-vivo-imaging-neuronal-glucose-concentrations-genetically-encoded)”. J Neurosci Res, 97, 8, Pp. 946-60. doi:10.1002/jnr.24433 - add\_circle do\_not\_disturb\_on Abstract Glucose is an essential source of energy for the brain. Recently, the development of genetically encoded fluorescent biosensors has allowed real time visualization of glucose dynamics from individual neurons and astrocytes. A major difficulty for this... Carlos Manlio Díaz-García and Gary Yellen. 2019. “[Neurons Rely on Glucose Rather Than Astrocytic Lactate During Stimulation](/publications/neurons-rely-glucose-rather-astrocytic-lactate-during-stimulation)”. J Neurosci Res, 97, 8, Pp. 883-89. doi:10.1002/jnr.24374 Carlos Manlio Díaz-García and Gary Yellen. 2019. “[Neurons Rely on Glucose Rather Than Astrocytic Lactate During Stimulation](/publications/neurons-rely-glucose-rather-astrocytic-lactate-during-stimulation)”. J Neurosci Res, 97, 8, Pp. 883-89. doi:10.1002/jnr.24374 - add\_circle do\_not\_disturb\_on Abstract Brain metabolism increases during stimulation, but this increase does not affect all energy metabolism equally. Briefly after stimulation, there is a local increase in cerebral blood flow and in glucose uptake, but a smaller increase in oxygen uptake... ### 2018 Gary Yellen. 2018. “[Fueling Thought: Management of Glycolysis and Oxidative Phosphorylation in Neuronal Metabolism](/publications/fueling-thought-management-glycolysis-and-oxidative-phosphorylation-neuronal)”. J Cell Biol, 217, 7, Pp. 2235-46. doi:10.1083/jcb.201803152 Gary Yellen. 2018. “[Fueling Thought: Management of Glycolysis and Oxidative Phosphorylation in Neuronal Metabolism](/publications/fueling-thought-management-glycolysis-and-oxidative-phosphorylation-neuronal)”. J Cell Biol, 217, 7, Pp. 2235-46. doi:10.1083/jcb.201803152 - add\_circle do\_not\_disturb\_on Abstract The brain's energy demands are remarkable both in their intensity and in their moment-to-moment dynamic range. This perspective considers the evidence for Warburg-like aerobic glycolysis during the transient metabolic response of the brain to acute... Juan Ramón Martínez-François, María Carmen Fernández-Agüera, Nidhi Nathwani, Carolina Lahmann, Veronica Burnham, Nika Danial, and Gary Yellen. 2018. “[BAD and K Channels Regulate Neuron Excitability and Epileptiform Activity](/publications/bad-and-k-channels-regulate-neuron-excitability-and-epileptiform-activity)”. Elife, 7. doi:10.7554/eLife.32721 Juan Ramón Martínez-François, María Carmen Fernández-Agüera, Nidhi Nathwani, Carolina Lahmann, Veronica Burnham, Nika Danial, and Gary Yellen. 2018. “[BAD and K Channels Regulate Neuron Excitability and Epileptiform Activity](/publications/bad-and-k-channels-regulate-neuron-excitability-and-epileptiform-activity)”. Elife, 7. doi:10.7554/eLife.32721 - add\_circle do\_not\_disturb\_on Abstract Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of *Bad* (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures... Jeannine Foley, Veronica Burnham, Meghan Tedoldi, Nika Danial, and Gary Yellen. 2018. “[BAD Knockout Provides Metabolic Seizure Resistance in a Genetic Model of Epilepsy With Sudden Unexplained Death in Epilepsy](/publications/bad-knockout-provides-metabolic-seizure-resistance-genetic-model-epilepsy-sudden)”. Epilepsia, 59, 1, Pp. e1-e4. doi:10.1111/epi.13960 Jeannine Foley, Veronica Burnham, Meghan Tedoldi, Nika Danial, and Gary Yellen. 2018. “[BAD Knockout Provides Metabolic Seizure Resistance in a Genetic Model of Epilepsy With Sudden Unexplained Death in Epilepsy](/publications/bad-knockout-provides-metabolic-seizure-resistance-genetic-model-epilepsy-sudden)”. Epilepsia, 59, 1, Pp. e1-e4. doi:10.1111/epi.13960 - add\_circle do\_not\_disturb\_on Abstract Metabolic alteration, either through the ketogenic diet (KD) or by genetic alteration of the BAD protein, can produce seizure protection in acute chemoconvulsant models of epilepsy. To assess the seizure-protective role of knocking out (KO) the Bad gene... [ View All Citations arrow\_circle\_right ](/publications) ## Recent Publications Download 6 citations download- [BibTeX](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1800106&content_filter%5B1%5D=1800111&content_filter%5B2%5D=1716711&content_filter%5B3%5D=1800116&content_filter%5B4%5D=1716721&content_filter%5B5%5D=1716716&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1800106&content_filter%5B1%5D=1800111&content_filter%5B2%5D=1716711&content_filter%5B3%5D=1800116&content_filter%5B4%5D=1716721&content_filter%5B5%5D=1716716&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1800106&content_filter%5B1%5D=1800111&content_filter%5B2%5D=1716711&content_filter%5B3%5D=1800116&content_filter%5B4%5D=1716721&content_filter%5B5%5D=1716716&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1800106&content_filter%5B1%5D=1800111&content_filter%5B2%5D=1716711&content_filter%5B3%5D=1800116&content_filter%5B4%5D=1716721&content_filter%5B5%5D=1716716&&format=tagged) - [Marc](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1800106&content_filter%5B1%5D=1800111&content_filter%5B2%5D=1716711&content_filter%5B3%5D=1800116&content_filter%5B4%5D=1716721&content_filter%5B5%5D=1716716&&format=marc) - [PubMedId](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1800106&content_filter%5B1%5D=1800111&content_filter%5B2%5D=1716711&content_filter%5B3%5D=1800116&content_filter%5B4%5D=1716721&content_filter%5B5%5D=1716716&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=no_pager&number_of_items=6&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1800106&content_filter%5B1%5D=1800111&content_filter%5B2%5D=1716711&content_filter%5B3%5D=1800116&content_filter%5B4%5D=1716721&content_filter%5B5%5D=1716716&&format=ris) ### 2024 Elisa York, Anne Miller, Sylwia Stopka, Juan Ramón Martínez-François, Md Amin Hossain, Gerard Baquer, Michael Regan, Nathalie Agar, and Gary Yellen. 2024. “[The Dentate Gyrus Differentially Metabolizes Glucose and Alternative Fuels During Rest and Stimulation](/publications/dentate-gyrus-differentially-metabolizes-glucose-and-alternative-fuels-during)”. J Neurochem. doi:10.1111/jnc.16004 Elisa York, Anne Miller, Sylwia Stopka, Juan Ramón Martínez-François, Md Amin Hossain, Gerard Baquer, Michael Regan, Nathalie Agar, and Gary Yellen. 2024. “[The Dentate Gyrus Differentially Metabolizes Glucose and Alternative Fuels During Rest and Stimulation](/publications/dentate-gyrus-differentially-metabolizes-glucose-and-alternative-fuels-during)”. J Neurochem. doi:10.1111/jnc.16004 - add\_circle do\_not\_disturb\_on Abstract The metabolic demands of neuronal activity are both temporally and spatially dynamic, and neurons are particularly sensitive to disruptions in fuel and oxygen supply. Glucose is considered an obligate fuel for supporting brain metabolism. Although... ### 2023 Anne Miller, Elisa York, Sylwia Stopka, Juan Ramón Martínez-François, Md Amin Hossain, Gerard Baquer, Michael Regan, Nathalie Agar, and Gary Yellen. 2023. “[Spatially Resolved Metabolomics and Isotope Tracing Reveal Dynamic Metabolic Responses of Dentate Granule Neurons With Acute Stimulation](/publications/spatially-resolved-metabolomics-and-isotope-tracing-reveal-dynamic-metabolic)”. Nat Metab, 5, 10, Pp. 1820-35. doi:10.1038/s42255-023-00890-z Anne Miller, Elisa York, Sylwia Stopka, Juan Ramón Martínez-François, Md Amin Hossain, Gerard Baquer, Michael Regan, Nathalie Agar, and Gary Yellen. 2023. “[Spatially Resolved Metabolomics and Isotope Tracing Reveal Dynamic Metabolic Responses of Dentate Granule Neurons With Acute Stimulation](/publications/spatially-resolved-metabolomics-and-isotope-tracing-reveal-dynamic-metabolic)”. Nat Metab, 5, 10, Pp. 1820-35. doi:10.1038/s42255-023-00890-z - add\_circle do\_not\_disturb\_on Abstract Neuronal activity creates an intense energy demand that must be met by rapid metabolic responses. To investigate metabolic adaptations in the neuron-enriched dentate granule cell (DGC) layer within its native tissue environment, we employed murine acute... Margarete Diaz-Cuadros, Teemu Miettinen, Owen Skinner, Dylan Sheedy, Carlos Manlio Díaz-García, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott Manalis, William Oldham, and Olivier Pourquié. 2023. “[Metabolic Regulation of Species-Specific Developmental Rates](/publications/metabolic-regulation-species-specific-developmental-rates)”. Nature, 613, 7944, Pp. 550-57. doi:10.1038/s41586-022-05574-4 Margarete Diaz-Cuadros, Teemu Miettinen, Owen Skinner, Dylan Sheedy, Carlos Manlio Díaz-García, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott Manalis, William Oldham, and Olivier Pourquié. 2023. “[Metabolic Regulation of Species-Specific Developmental Rates](/publications/metabolic-regulation-species-specific-developmental-rates)”. Nature, 613, 7944, Pp. 550-57. doi:10.1038/s41586-022-05574-4 - add\_circle do\_not\_disturb\_on Abstract Animals display substantial inter-species variation in the rate of embryonic development despite a broad conservation of the overall sequence of developmental events. Differences in biochemical reaction rates, including the rates of protein production and... ### 2022 Ahmed Abdelfattah, Sapna Ahuja, Taner Akkin, Srinivasa Rao Allu, Joshua Brake, David Boas, Erin Buckley, Robert Campbell, Anderson Chen, Xiaojun Cheng, Tomáš Čižmár, Irene Costantini, Massimo De Vittorio, Anna Devor, Patrick Doran, Mirna El Khatib, Valentina Emiliani, Natalie Fomin-Thunemann, Yeshaiahu Fainman, Tomas Fernandez-Alfonso, Christopher Ferri, Ariel Gilad, Xue Han, Andrew Harris, Elizabeth Hillman, Ute Hochgeschwender, Matthew Holt, Na Ji, Kıvılcım Kılıç, Evelyn Lake, Lei Li, Tianqi Li, Philipp Mächler, Evan Miller, Rickson Mesquita, Naga Srinivas Nadella, Valentin Nägerl, Yusuke Nasu, Axel Nimmerjahn, Petra Ondráčková, Francesco Pavone, Citlali Perez Campos, Darcy Peterka, Filippo Pisano, Ferruccio Pisanello, Francesca Puppo, Bernardo Sabatini, Sanaz Sadegh, Sava Sakadzic, Shy Shoham, Sanaya Shroff, Angus Silver, Ruth Sims, Spencer Smith, Vivek Srinivasan, Martin Thunemann, Lei Tian, Lin Tian, Thomas Troxler, Antoine Valera, Alipasha Vaziri, Sergei Vinogradov, Flavia Vitale, Lihong Wang, Hana Uhlířová, Chris Xu, Changhuei Yang, Mu-Han Yang, Gary Yellen, Ofer Yizhar, and Yongxin Zhao. 2022. “[Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report](/publications/neurophotonic-tools-microscopic-measurements-and-manipulation-status-report)”. Neurophotonics, 9, Suppl 1, Pp. 013001. doi:10.1117/1.NPh.9.S1.013001 Ahmed Abdelfattah, Sapna Ahuja, Taner Akkin, Srinivasa Rao Allu, Joshua Brake, David Boas, Erin Buckley, Robert Campbell, Anderson Chen, Xiaojun Cheng, Tomáš Čižmár, Irene Costantini, Massimo De Vittorio, Anna Devor, Patrick Doran, Mirna El Khatib, Valentina Emiliani, Natalie Fomin-Thunemann, Yeshaiahu Fainman, Tomas Fernandez-Alfonso, Christopher Ferri, Ariel Gilad, Xue Han, Andrew Harris, Elizabeth Hillman, Ute Hochgeschwender, Matthew Holt, Na Ji, Kıvılcım Kılıç, Evelyn Lake, Lei Li, Tianqi Li, Philipp Mächler, Evan Miller, Rickson Mesquita, Naga Srinivas Nadella, Valentin Nägerl, Yusuke Nasu, Axel Nimmerjahn, Petra Ondráčková, Francesco Pavone, Citlali Perez Campos, Darcy Peterka, Filippo Pisano, Ferruccio Pisanello, Francesca Puppo, Bernardo Sabatini, Sanaz Sadegh, Sava Sakadzic, Shy Shoham, Sanaya Shroff, Angus Silver, Ruth Sims, Spencer Smith, Vivek Srinivasan, Martin Thunemann, Lei Tian, Lin Tian, Thomas Troxler, Antoine Valera, Alipasha Vaziri, Sergei Vinogradov, Flavia Vitale, Lihong Wang, Hana Uhlířová, Chris Xu, Changhuei Yang, Mu-Han Yang, Gary Yellen, Ofer Yizhar, and Yongxin Zhao. 2022. “[Neurophotonic Tools for Microscopic Measurements and Manipulation: Status Report](/publications/neurophotonic-tools-microscopic-measurements-and-manipulation-status-report)”. Neurophotonics, 9, Suppl 1, Pp. 013001. doi:10.1117/1.NPh.9.S1.013001 - add\_circle do\_not\_disturb\_on Abstract *Neurophotonics* was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, *Neurophotonics*' agenda has been well aligned with this focus on... Dorothy Koveal, Paul Rosen, Dylan Meyer, Carlos Manlio Díaz-García, Yongcheng Wang, Li-Heng Cai, Peter Chou, David Weitz, and Gary Yellen. 2022. “[A High-Throughput Multiparameter Screen for Accelerated Development and Optimization of Soluble Genetically Encoded Fluorescent Biosensors](/publications/high-throughput-multiparameter-screen-accelerated-development-and-optimization)”. Nat Commun, 13, 1, Pp. 2919. doi:10.1038/s41467-022-30685-x Dorothy Koveal, Paul Rosen, Dylan Meyer, Carlos Manlio Díaz-García, Yongcheng Wang, Li-Heng Cai, Peter Chou, David Weitz, and Gary Yellen. 2022. “[A High-Throughput Multiparameter Screen for Accelerated Development and Optimization of Soluble Genetically Encoded Fluorescent Biosensors](/publications/high-throughput-multiparameter-screen-accelerated-development-and-optimization)”. Nat Commun, 13, 1, Pp. 2919. doi:10.1038/s41467-022-30685-x - add\_circle do\_not\_disturb\_on Abstract Genetically encoded fluorescent biosensors are powerful tools used to track chemical processes in intact biological systems. However, the development and optimization of biosensors remains a challenging and labor-intensive process, primarily due to... Dylan Meyer, Carlos Manlio Díaz-García, Nidhi Nathwani, Mahia Rahman, and Gary Yellen. 2022. “[The Na K Pump Dominates Control of Glycolysis in Hippocampal Dentate Granule Cells](/publications/nak-pump-dominates-control-glycolysis-hippocampal-dentate-granule-cells)”. Elife, 11. doi:10.7554/eLife.81645 Dylan Meyer, Carlos Manlio Díaz-García, Nidhi Nathwani, Mahia Rahman, and Gary Yellen. 2022. “[The Na K Pump Dominates Control of Glycolysis in Hippocampal Dentate Granule Cells](/publications/nak-pump-dominates-control-glycolysis-hippocampal-dentate-granule-cells)”. Elife, 11. doi:10.7554/eLife.81645 - add\_circle do\_not\_disturb\_on Abstract Cellular ATP that is consumed to perform energetically expensive tasks must be replenished by new ATP through the activation of metabolism. Neuronal stimulation, an energetically demanding process, transiently activates aerobic glycolysis, but the precise... [ More arrow\_circle\_right ](/publications)