Yellen Lab Publications

Publication Date
2000 -

Giménez-Cassina A, Martínez-François JR, Fisher JK, Szlyk B, Polak K, Wiwczar J, Tanner GR, Lutas A, Yellen G*, Danial NN*.   BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures.  Neuron 2012 May 24;74(4):719-730. Journal link  *co-corresponding authors  Preview by Ziviani and Scorrano

Kwan DC, Prole DL, Yellen G.  Structural changes during HCN channel gating defined by high affinity metal bridges.  J Gen Physiol 2012;140(3):279-291. pdf; Commentary by Trudeau

Ryu S, Yellen G.  Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.  J Gen Physiol 2012;140(5):469-479. pdf; Commentary by Trudeau

Hung YP, Albeck JG, Tantama M, Yellen G.  Imaging Cytosolic NADH-NAD+ Redox State with a Genetically Encoded Fluorescent Biosensor.  Cell Metab. 2011 Oct 5;14(4):545-54. Journal Link (Featured Article) pdf, Supplement pdf

Tanner GR, Lutas A, Martínez-François JR, Yellen G.  Single KATP channel opening in response to action potential firing in mouse dentate granule neurons.  J Neurosci. 2011 Jun 8;31(23):8689-96. Free from the journal

Tantama M, Hung YP, Yellen G.  Imaging intracellular pH in live cells with a genetically encoded red fluorescent protein sensor.  J Am Chem Soc. 2011 Jul 6;133(26):10034-7. Epub 2011 Jun 9. Free from Pubmed Central

Berg J, Hung YP, Yellen G.  A genetically encoded fluorescent reporter of ATP:ADP ratio.  Nat Methods. 2009 Feb;6(2):161-6. Epub 2009 Jan 4. pdf, Supplement pdf

Yellen G.  Ketone bodies, glycolysis, and KATP channels in the mechanism of the ketogenic diet.  Epilepsia. 2008 Nov;49 Suppl 8:80-2. pdf

Ma W, Berg J, Yellen G.  Ketogenic diet metabolites reduce firing in central neurons by opening KATP channels.  J Neurosci. 2007 Apr 4;27(14):3618-25. free via Pubmed

Dekker JP, Yellen G.  Cooperative gating between single HCN pacemaker channels.  J Gen Physiol. 2006 Nov;128(5):561-7. Epub 2006 Oct 16. free via Pubmed

Prole DL, Yellen G.  Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.  J Gen Physiol. 2006 Sep;128(3):273-82. Epub 2006 Aug 14. free via Pubmed

Proenza C, Yellen G.  Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents.  J Gen Physiol. 2006 Feb;127(2):183-90. free via Pubmed

del Camino D, Kanevsky M, Yellen G.  Status of the intracellular gate in the activated-not-open state of Shaker K+ channels.  J Gen Physiol. 2005 Nov;126(5):419-28. free via Pubmed

Webster SM, Del Camino D, Dekker JP, Yellen G.  Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.  Nature. 2004 Apr 22;428(6985):864-8. pdf

Shin KS, Maertens C, Proenza C, Rothberg BS, Yellen G.  Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage.  Neuron. 2004 Mar 4;41(5):737-44. pdf

Dekker JP, Fodor A, Aldrich RW, Yellen G.  A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments.  Bioinformatics. 2004 Jul 10;20(10):1565-72. Epub 2004 Feb 12. free via Pubmed

Rothberg BS, Shin KS, Yellen G.  Movements near the gate of a hyperpolarization-activated cation channel.  J Gen Physiol. 2003 Nov;122(5):501-10. Epub 2003 Oct 13. free via Pubmed

Yellen G.  The voltage-gated potassium channels and their relatives.  Nature. 2002 Sep 5;419(6902):35-42. pdf

Smith PL, Yellen G.  Fast and slow voltage sensor movements in HERG potassium channels.  J Gen Physiol. 2002 Mar;119(3):275-93. free via Pubmed

Rothberg BS, Shin KS, Phale PS, Yellen G.  Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel.  J Gen Physiol. 2002 Jan;119(1):83-91. free via Pubmed

Yellen G.  Keeping K+ completely comfortable.  Nat Struct Biol. 2001 Dec;8(12):1011-3.

del Camino D, Yellen G.  Tight steric closure at the intracellular activation gate of a voltage-gated K+ channel.  Neuron. 2001 Nov 20;32(4):649-56. pdf

Yellen G.  Dimers among friends: ion channel regulation by dimerization of tail domains.  Trends Pharmacol Sci. 2001 Sep;22(9):439-41.

Shin KS, Rothberg BS, Yellen G.  Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate.  J Gen Physiol. 2001 Feb;117(2):91-101. free via Pubmed

del Camino D, Holmgren M, Liu Y, Yellen G.  Blocker protection in the pore of a voltage-gated K+ channel and its structural implications.  Nature. 2000 Jan 20;403(6767):321-5. pdf

1990 - 1999

Yellen G.  The bacterial K+ channel structure and its implications for neuronal channels.  Curr Opin Neurobiol. 1999 Jun;9(3):267-73.

Yellen G.  The moving parts of voltage-gated ion channels.  Q Rev Biophys. 1998 Aug;31(3):239-95. pdf

Holmgren M, Shin KS, Yellen G.  The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge.  Neuron. 1998 Sep;21(3):617-21. pdf

Yellen G.  Premonitions of ion channel gating.  Nat Struct Biol. 1998 Jun;5(6):421.

Yellen G.  Single channel seeks permeant ion for brief but intimate relationship.  J Gen Physiol. 1997 Aug;110(2):83-5. free via Pubmed

Liu Y, Holmgren M, Jurman ME, Yellen G.  Gated access to the pore of a voltage-dependent K+ channel.  Neuron. 1997 Jul;19(1):175-84. pdf

Holmgren M, Smith PL, Yellen G.  Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating.  J Gen Physiol. 1997 May;109(5):527-35. free via Pubmed

Baker K, Warren KS, Yellen G, Fishman MC.  Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate.  Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4554-9. free via Pubmed

Baukrowitz T, Yellen G.  Two functionally distinct subsites for the binding of internal blockers to the pore of voltage-activated K+ channels.  Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13357-61. free via Pubmed

Holmgren M, Jurman ME, Yellen G.  N-type inactivation and the S4-S5 region of the Shaker K+ channel.  J Gen Physiol. 1996 Sep;108(3):195-206. free via Pubmed

Forman SA, Yellen G, Thiele EA.  Alternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation.  Nat Genet. 1996 Aug;13(4):396-7. pdf

Liu Y, Jurman ME, Yellen G.  Dynamic rearrangement of the outer mouth of a K+ channel during gating.  Neuron. 1996 Apr;16(4):859-67. pdf

Smith PL, Baukrowitz T, Yellen G.  The inward rectification mechanism of the HERG cardiac potassium channel.  Nature. 1996 Feb 29;379(6568):833-6. pdf

Baukrowitz T, Yellen G.  Use-dependent blockers and exit rate of the last ion from the multi-ion pore of a K+ channel.  Science. 1996 Feb 2;271(5249):653-6. pdf

Holmgren M, Liu Y, Xu Y, Yellen G.  On the use of thiol-modifying agents to determine channel topology.  Neuropharmacology. 1996;35(7):797-804. pdf

Baukrowitz T, Yellen G. Modulation of K+ current by frequency and external K+: a tale of two inactivation mechanisms. Neuron. 1995 Oct;15(4):951-60. pdf

Forman SA, Miller KW, Yellen G.  A discrete site for general anesthetics on a postsynaptic receptor.  Mol Pharmacol. 1995 Oct;48(4):574-81.

McLaughlin JT, Hawrot E, Yellen G.  Covalent modification of engineered cysteines in the nicotinic acetylcholine receptor agonist-binding domain inhibits receptor activation.  Biochem J. 1995 Sep 15;310 ( Pt 3):765-9. free via Pubmed

Jurman ME, Boland LM, Liu Y, Yellen G.  Visual identification of individual transfected cells for electrophysiology using antibody-coated beads.  Biotechniques. 1994 Nov;17(5):876-81.

Yellen G, Sodickson D, Chen TY, Jurman ME.  An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding.  Biophys J. 1994 Apr;66(4):1068-75. free via Pubmed

Boland LM, Jurman ME, Yellen G.  Cysteines in the Shaker K+ channel are not essential for channel activity or zinc modulation.  Biophys J. 1994 Mar;66(3 Pt 1):694-9. free via Pubmed

Kienker P, Tomaselli G, Jurman M, Yellen G.  Conductance mutations of the nicotinic acetylcholine receptor do not act by a simple electrostatic mechanism.  Biophys J. 1994 Feb;66(2 Pt 1):325-34. free via Pubmed

Yellen G.  Calcium channels. Structure and selectivity.  Nature. 1993 Nov 11;366(6451):109-10.

Choi KL, Mossman C, Aube J, Yellen G.  The internal quaternary ammonium receptor site of Shaker potassium channels.  Neuron. 1993 Mar;10(3):533-41. pdf

Hwang PM, Glatt CE, Bredt DS, Yellen G, Snyder SH.  A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization.  Neuron. 1992 Mar;8(3):473-81.

Demo SD, Yellen G.  Ion effects on gating of the Ca2+-activated K+ channel correlate with occupancy of the pore.  Biophys J. 1992 Mar;61(3):639-48. free via Pubmed

Demo SD, Yellen G.  The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker.  Neuron. 1991 Nov;7(5):743-53. pdf

Tomaselli GF, McLaughlin JT, Jurman ME, Hawrot E, Yellen G.  Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor.  Biophys J. 1991 Sep;60(3):721-7. free via Pubmed

Choi KL, Aldrich RW, Yellen G.  Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels.  Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5092-5. free via Pubmed

Yellen G, Jurman ME, Abramson T, MacKinnon R.  Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel.  Science. 1991 Feb 22;251(4996):939-42. pdf

MacKinnon R, Yellen G.  Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels.  Science. 1990 Oct 12;250(4978):276-9. pdf

Tomaselli GF, Feldman AM, Yellen G, Marban E.  Human cardiac sodium channels expressed in Xenopus oocytes.  Am J Physiol. 1990 Mar;258(3 Pt 2):H903-6.

Yellen G, Migeon JC.  Expression of Torpedo nicotinic acetylcholine receptor subunits in yeast is enhanced by use of yeast signal sequences.  Gene. 1990 Feb 14;86(2):145-52.

1982 - 1989

Tomaselli GF, Marban E, Yellen G.  Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin.  J Clin Invest. 1989 May;83(5):1724-32.

Yellen G.  Permeation in potassium channels: implications for channel structure.  Annu Rev Biophys Biophys Chem. 1987;16:227-46.

Cukierman S, Yellen G, Miller C.  The K+ channel of sarcoplasmic reticulum. A new look at Cs+ block.  Biophys J. 1985 Sep;48(3):477-84. free via Pubmed

Yellen G.  Relief of Na+ block of Ca2+-activated K+ channels by external cations.  J Gen Physiol. 1984 Aug;84(2):187-99. free via Pubmed

Yellen G.  Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cells.  J Gen Physiol. 1984 Aug;84(2):157-86. free via Pubmed

Reuter H, Stevens CF, Tsien RW, Yellen G.  Properties of single calcium channels in cardiac cell culture.  Nature. 1982 Jun 10;297(5866):501-4.

Yellen G.  Single Ca2+-activated nonselective cation channels in neuroblastoma.  Nature. 1982 Mar 25;296(5855):357-9.

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